Bulg. J. Phys. vol.27 no.S3 (2000), pp. 242-245

Fast Neutrons Radiotherapy and Treatments with Drugs Bearing-SH Groups

L. Radu1, B. Constantinescu2, D. Gazdara3, I. Radulescu1
1Department of Molecular Genetics, V.Babes Institute, Bucharest, Romania
2Department of Cyclotron, Instttute of Atomic Physics, Bucharest, Romania
3'Department of Biophysics, Physics Faculty, Bucharest University, Romania
Abstract. Chromatin, extracted from Walker carcinosarcoma maintained on Wistar rats, was irradiated with fast neutrons, in absence and in presence of N-acetylcysteine or captopril. The chromatin structure modifications were tested by determination of emission characteristics of chromatin complexes with a specific DNA ligand, by analysis of chromatin intrinsic fluorescence and by determination of energy transfer between two specific ligands coupled at chromatin.

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