Abstract. A peptide can be used as a functional building block to create artificial structures when there is sufficient displacement and functional ability in terms of its assigned function. The nature and the relative strength of the intermolecular interactions between the components of the liquid mixtures/solutions have been investigated by ultrasonic method. In the present study density (ρ), ultrasonic velocity (u) and viscosity (η) of the ternary solutions of peptide-amide with electrolyte have been measured at 298.15, 308.15 and 318.15 K respectively, over the entire composition range using digital density meter, ultrasonic interferometer and Cannon Fenske viscometer respectively. The measured data have been used to compute the thermodynamic parameters such as internal pressure and free volume. The results have been analyzed on the basis of variation in concentrations and temperatures. The results obtained from the ultrasonic methods using the basic parameters have been correlated with FT-IR and Antimicrobial studies and they have been interpreted in terms of peptide-amide interactions. An attempt is made to corroborate the thermodynamic, experimental FT-IR and antimicrobial studies of non-aqueous peptide solutions.

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